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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5458 | Darusentan | Lu-135252 | Endothelin Receptor |
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries | |||
T3194 | Ro 46-2005 | Endothelin Receptor | |
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM). | |||
T2561 | Macitentan | ACT-064992 | Apoptosis , Endothelin Receptor |
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). | |||
T3474 | RO 46-8443 | Endothelin Receptor | |
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. | |||
T5355 | Sparsentan | RE-021,DARA-a | RAAS , Endothelin Receptor |
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively) | |||
T2026 | CYM5442 | S1P Receptor , LPL Receptor | |
CYM5442 is an S1P agonist, targeting to Sphingosine. | |||
T6792 | BQ-123 | BQ123 | Endothelin Receptor |
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. | |||
T6264 | Bosentan | Actelion,Ro 47-0203,Benzenesulfonamide | Endothelin Receptor |
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th... | |||
TQ0282 | Avosentan | SPP-301,Ro 67-0565 | Endothelin Receptor |
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor). | |||
T0750 | Sulfisoxazole | NU-445,Sulfafurazole | Endothelin Receptor , Antibacterial , Antibiotic , Autophagy |
Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting ... | |||
T6258 | Zibotentan | ZD4054 | Apoptosis , Endothelin Receptor |
Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. | |||
T1655 | Ambrisentan | BSF-208075,BSF 208075,LU 208075 | Endothelin Receptor |
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha... | |||
T6265 | Bosentan (hydrate) | Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203 | Endothelin Receptor |
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. | |||
TQ0259 | Atrasentan | A-147627,(+)-A 127722,ABT-627 | Endothelin Receptor |
Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA). | |||
T6672 | Sitaxsentan sodium | TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium | Endothelin Receptor |
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors. | |||
T7817 | Aprocitentan | ACT-132577 | Endothelin Receptor |
Aprocitentan (ACT-132577) is ETA and ETB antagonist . | |||
TQ0270 | Atrasentan hydrochloride | (+)-A 127722 hydrochloride,ABT-627 hydrochloride,A-147627 hydrochloride | Endothelin Receptor |
Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA). | |||
T15596 | IRL 2500 | Endothelin Receptor | |
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor. | |||
T12924 | Sitaxsentan | TBC-11251,IPI 1040 | Endothelin Receptor |
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to its receptors, thereby eliminating the harmful ef... | |||
TP2262L | IRL-1038 acetate | IRL-1038 acetate(144602-02-8 Free base) | Endothelin Receptor |
IRL-1038 acetate is a potent ETB endothelin receptor antagonist. |