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Search Results for " endothelin receptor "

20

Compounds

Cat No. Product Name Synonyms Targets
T5458 Darusentan Lu-135252 Endothelin Receptor
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries
T3194 Ro 46-2005 Endothelin Receptor
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM).
T2561 Macitentan ACT-064992 Apoptosis , Endothelin Receptor
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T3474 RO 46-8443 Endothelin Receptor
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
T5355 Sparsentan RE-021,DARA-a RAAS , Endothelin Receptor
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
T2026 CYM5442 S1P Receptor , LPL Receptor
CYM5442 is an S1P agonist, targeting to Sphingosine.
T6792 BQ-123 BQ123 Endothelin Receptor
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T6264 Bosentan Actelion,Ro 47-0203,Benzenesulfonamide Endothelin Receptor
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th...
TQ0282 Avosentan SPP-301,Ro 67-0565 Endothelin Receptor
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
T0750 Sulfisoxazole NU-445,Sulfafurazole Endothelin Receptor , Antibacterial , Antibiotic , Autophagy
Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting ...
T6258 Zibotentan ZD4054 Apoptosis , Endothelin Receptor
Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T1655 Ambrisentan BSF-208075,BSF 208075,LU 208075 Endothelin Receptor
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha...
T6265 Bosentan (hydrate) Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203 Endothelin Receptor
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
TQ0259 Atrasentan A-147627,(+)-A 127722,ABT-627 Endothelin Receptor
Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T6672 Sitaxsentan sodium TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium Endothelin Receptor
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
T7817 Aprocitentan ACT-132577 Endothelin Receptor
Aprocitentan (ACT-132577) is ETA and ETB antagonist .
TQ0270 Atrasentan hydrochloride (+)-A 127722 hydrochloride,ABT-627 hydrochloride,A-147627 hydrochloride Endothelin Receptor
Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).
T15596 IRL 2500 Endothelin Receptor
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
T12924 Sitaxsentan TBC-11251,IPI 1040 Endothelin Receptor
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to its receptors, thereby eliminating the harmful ef...
TP2262L IRL-1038 acetate IRL-1038 acetate(144602-02-8 Free base) Endothelin Receptor
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.

Compounds

Darusentan
T5458
Synonym: Lu-135252
Target: Endothelin Receptor
Ro 46-2005
T3194
Synonym:
Target: Endothelin Receptor
Macitentan
T2561
Synonym: ACT-064992
Target: Apoptosis, Endothelin Receptor
RO 46-8443
T3474
Synonym:
Target: Endothelin Receptor
Sparsentan
T5355
Synonym: RE-021,DARA-a
Target: RAAS, Endothelin Receptor
CYM5442
T2026
Synonym:
Target: S1P Receptor, LPL Receptor
BQ-123
T6792
Synonym: BQ123
Target: Endothelin Receptor
Bosentan
T6264
Synonym: Actelion,Ro 47-0203,Benzenesulfonamide
Target: Endothelin Receptor
Avosentan
TQ0282
Synonym: SPP-301,Ro 67-0565
Target: Endothelin Receptor
Sulfisoxazole
T0750
Synonym: NU-445,Sulfafurazole
Target: Endothelin Receptor, Antibacterial, Antibiotic, Autophagy
Zibotentan
T6258
Synonym: ZD4054
Target: Apoptosis, Endothelin Receptor
Ambrisentan
T1655
Synonym: BSF-208075,BSF 208075,LU 208075
Target: Endothelin Receptor
Bosentan (hydrate)
T6265
Synonym: Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203
Target: Endothelin Receptor
Atrasentan
TQ0259
Synonym: A-147627,(+)-A 127722,ABT-627
Target: Endothelin Receptor
Sitaxsentan sodium
T6672
Synonym: TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium
Target: Endothelin Receptor
Aprocitentan
T7817
Synonym: ACT-132577
Target: Endothelin Receptor
Atrasentan hydrochloride
TQ0270
Synonym: (+)-A 127722 hydrochloride,ABT-627 hydrochloride,A-147627 hydrochloride
Target: Endothelin Receptor
IRL 2500
T15596
Synonym:
Target: Endothelin Receptor
Sitaxsentan
T12924
Synonym: TBC-11251,IPI 1040
Target: Endothelin Receptor
IRL-1038 acetate
TP2262L
Synonym: IRL-1038 acetate(144602-02-8 Free base)
Target: Endothelin Receptor
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TargetMol